Congratulations to Sairam Jabba for his Duke Neurogenetics Travel Award

Congratulations, Dr. Jorg Grandl has been selected for a Klingenstein Fellowship Award in the Neurosciences!


New Publications:

Sairam Jabba, Raman Goyal, Jason O. Sosa-Pagán, Hans Moldenhauer, Jason Wu, Breanna Kalmeta, Michael Bandell, Ramon Latorre, Ardem Patapoutian and Jörg Grandl. Directionality of temperature-activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six. Neuron, in press.

The Auxiliary Subunit KChIP2 is an Essential Regulator of Homeostatic Excitability
Hong-Gang Wang, Xiao Ping He, Qiang Li, Roger D. Madison, Scott D. Moore, James O. McNamara, and Geoffrey S. Pitt
J. Biol. Chem. published 27 March 2013, 10.1074/jbc.M112.434548

Cytoskeletal regulation of TRPC channels in the cardiorenal system.
Stiber JA, Tang Y, Li T, Rosenberg PB.
Curr Hypertens Rep. 2012 Dec;14(6):492-7. doi: 10.1007/s11906-012-0313-4.

Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development.
Ramachandran KV, Hennessey JA, Barnett AS, Yin X, Stadt HA, Foster E, Shah RA, Yazawa RA, Dolmetsch RE, Kirby ML, Pitt GS
Journal of Clinical Investigation, in press




The Ion Channel Research Unit aims to bring together a multi-disciplinary group of researchers, without departmental boundaries, who focus on membrane excitability/bioelectricity to address diseases caused by defects in ion channel function.

An ever-increasing number of disorders, such cardiac arrhythmias, epilepsy, ataxias, migraines, diabetes, and end-stage renal disease, are attributable to ion channel dysfunction. Because specific ion channels expressed in one tissue are identical or similar to ion channels expressed in another tissue, these apparently disparate “channelopathies” often share certain features. For example, mutations in the retinal Ca2+ channel cause night blindness, and defects in a homologous Ca2+ channel expressed in multiple tissues result in a multi-system disorder including cognitive abnormalities, hyperglycemia, cardiac arrhythmias, and developmental defects. Investigation of one type of ion channel from multiple perspectives can thus catalyze efforts to understand a range of channelopathies. »» more



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