Congratulations to Malcolm McDonald for being awarded a Dean’s Summer Research Fellowship!
Amanda H Lewis and Jörg Grandl. Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension. eLife (2015), DOI 10.7554/eLife.12088
2015-2016 SEMINAR SERIES SCHEDULE
The Ion Channel Research Unit aims to bring together a multi-disciplinary
group of researchers, without departmental boundaries, who focus
on membrane excitability/bioelectricity to address diseases caused
by defects in ion channel function.
An ever-increasing number of disorders,
such cardiac arrhythmias, epilepsy, ataxias, migraines, diabetes,
and end-stage renal disease, are attributable to ion channel dysfunction.
Because specific ion channels expressed in one tissue are identical
or similar to ion channels expressed in another tissue, these apparently
disparate “channelopathies” often
share certain features. For example, mutations in the retinal Ca2+
channel cause night blindness, and defects in a homologous Ca2+ channel
expressed in multiple tissues result in a multi-system disorder including
cognitive abnormalities, hyperglycemia, cardiac arrhythmias, and
developmental defects. Investigation of one type of ion channel from multiple
perspectives can thus catalyze efforts to understand a range of channelopathies. »» more